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Nerves (yellow)

A nerve is an enclosed, cable-like bundle of axons (the long, slender projection of a neuron). Neurons are sometimes called nerve cells, though this term is technically imprecise since many neurons do not form nerves, and nerves also include the non-axon glial cells that ensheath the axons in myelin.
Anatomy
Nerves are part of the Peripheral Nervous System . Afferent nerves convey sensory signals to the Central Nervous System, for example from skin or organs, while efferent nerves conduct stimulatory signals from the central nervous system to the muscles and glands. Afferent and efferent axons are often arranged together, forming mixed nerves. For example, the median nerve controls motor and sensory function in the hand.
Billions of long nerve cells, called neurons, make up the body's nervous system. Neurons receive and transmit chemical-electrical messages to and from the brain. Each neuron is long and thin. One end receives messages and the other transmits the message to the next neuron. The messages "jump" across a gap from one neuron cell to another.
Each peripheral nerve is covered externally by a dense sheath of connective tissue, the epineurium. Underlying this is a layer of flat cells forming a complete sleeve, the perineurium. Perineurial septae extend into the nerve and subdivide it into several bundles of fibres. Surrounding each such fibre is the endoneurial sheath. This forms an unbroken tube which extends from the surface of the spinal cord to the level at which the axon synapses with its muscle fibres or ends in sensory receptors. The endoneurial sheath consists of an inner sleeve of material called the glycocalyx and an outer, delicate, meshwork of collagen fibres. Peripheral nerves are richly supplied with blood.
Most nerves connect to the Central Nervous System through the spinal cord. The twelve cranial nerves, however, connect directly to parts of the brain. Spinal nerves are given letter-number combinations according to the vertebra through which they connect to the spinal column. Cranial nerves are assigned numbers, usually expressed as Roman numerals from I to XII. In addition, most major nerves have descriptive names. Inside the central nervous system, distinguishable bundles of axons are termed tracts rather than nerves.
The signals that nerves carry, sometimes called nerve impulses, are also known as action potentials. These are rapidly (up to 120 m/s) traveling electrical waves, which typically begin in the cell body of a neuron and propagate down the axon to its tip or "terminus." The signals cross over from the terminus of the axon to the adjacent neurotransmitter receptor through a gap called the synapse. Motor neurons innervate or activate muscles groups.
Clinical importance
Damage to nerves can be caused by physical injury, swelling (e.g. carpal tunnel syndrome), autoimmune diseases (e.g. Guillain-Barre Syndrome), infection (neuritis), Diabetes, or failure of the blood vessels surrounding the nerve. A pinched nerve occurs when pressure is placed on a nerve, usually from swelling due to an injury or pregnancy. Nerve damage or pinched nerves are usually accompanied by pain, numbness, weakness, or paralysis. Patients may feel these symptoms in areas far from the actual site of damage, a phenomenon called referred pain. Referred pain occurs because when a nerve is damaged, signalling is defective from all parts of the area from which the nerve receives input, not just the site of the damage. Neurologists usually diagnose disorders of the nerves by a physical examination, including the testing of reflexes, walking and other directed movements, muscle weakness, proprioception, and the sense of touch. This initial exam can be followed with tests such as nerve conduction study and electromyography (EMG).
See also
Nervous System
Dermatome (Anatomy)
Nerve injury
Additional images

Peripheral nerve, cross section
v • d • eNerves:
spinal nerves
Cervical (8)
C1, C2, C3, C4, C5, C6, C7, C8anterior (Cervical plexus, Brachial plexus) - posterior (Posterior branches of cervical nerves, Suboccipital - C1, Greater occipital - C2, Third occipital - C3)
Thoracic (12)
T1, T2, T3, T4, T5, T6, T7, T8, T9, T10, T11, T12anterior (Intercostal, Intercostobrachial - T2, Thoraco-abdominal nerves - T7-T11, Subcostal - T12) - posterior (Posterior branches of thoracic nerves)
Lumbar (5)
L1, L2, L3, L4, L5anterior (Lumbar plexus, Lumbosacral trunk) - posterior (Posterior branches of the lumbar nerves, Superior cluneal L1-L3)
Sacral (5)
S1, S2, S3, S4, S5anterior (Sacral plexus) - posterior (Posterior branches of sacral nerves, Medial cluneal nerves)
Coccygeal (1)
anterior (Coccygeal plexus) - posterior (Posterior branch of coccygeal nerve)
v • d • eNerves of head and neck:
the cranial nerves
olfactory (AON->I)
olfactory bulb - olfactory tract
optic (LGN->II)
optic chiasm - optic tract
oculomotor (ON,EWN->III)
superior branch (parasympathetic root of ciliary ganglion/ciliary ganglion) - inferior branch
trochlear (TN->IV)
no significant branches
trigeminal (PSN,TSN,MN,TMN->V)
trigeminal ganglion • ophthalmic • maxillary • mandibular
abducens (AN->VI)
no significant branches
facial (FMN,SN,SSN->VII)
near origin
nervus intermedius • geniculate
inside facial canal
greater petrosal (pterygopalatine ganglion) - nerve to the stapedius - chorda tympani (lingual nerve, submandibular ganglion)
at stylomastoid foramen
posterior auricular - suprahyoid (digastric, stylohyoid) - parotid plexus (temporal, zygomatic, buccal, mandibular, cervical)
vestibulocochlear (VN,CN->VIII)
cochlear (striae medullares, lateral lemniscus) • vestibular (Scarpa's ganglion)
glossopharyngeal (NA,ISN,SN->IX)
before jugular fossa
ganglia (superior, inferior)
after jugular fossa
tympanic (tympanic plexus, lesser petrosal, otic ganglion) • stylopharyngeal branch • pharyngeal branches • tonsillar branches • lingual branches • carotid sinus
vagus (NA,DNVN,SN->X)
before jugular fossa
ganglia (superior, inferior)
after jugular fossa
meningeal branch - auricular branch
neck
pharyngeal branch (pharyngeal plexus) - superior laryngeal (external, internal) - recurrent laryngeal (inferior) - superior cervical cardiac
thorax
inferior cardiac - pulmonary - vagal trunks (anterior, posterior)
abdomen
celiac - renal - hepatic - anterior gastric - posterior gastric
accessory (NA,SAN->XI)
cranial - spinal
hypoglossal (HN->XII)
lingual branches
v • d • eNerves of head and neck: the cervical plexus (C1-C4)
superficial
C2-C3: Lesser occipital • Greater auricular • Transverse cervicalC3-C4: Supraclavicular
deep
C1-C3: Ansa cervicalis (superior root, inferior root)C3-C5: Phrenic
v • d • eNerves of upper limbs (primarily): the brachial plexus (C5-T1)
Supraclavicular
root (dorsal scapular, long thoracic) - upper trunk (suprascapular, to the subclavius)
Infraclavicular: lateral cord
lateral pectoral
musculocutaneous (lateral cutaneous of forearm)median/lateral root: anterior interosseous - palmar - recurrent - common palmar digital (proper palmar digital)
Infraclavicular: medial cord
medial pectoral
cutaneous: medial cutaneous of forearm • medial cutaneous of arm
ulnar: muscular - palmar - dorsal (dorsal digital nerves) - superficial (common palmar digital, proper palmar digital) - deepmedian/medial root: see above
Infraclavicular: posterior cord
subscapular (upper, lower) • thoracodorsal
axillary (superior lateral cutaneous of arm)radial: muscular - cutaneous (posterior of arm, inferior lateral of arm, posterior of forearm) - superficial (dorsal digital nerves) - deep (posterior interosseous)
Other
cutaneous innervation of the upper limbs
v • d • eNerves - autonomic nervous system (sympathetic nervous system/ganglion/trunks and parasympathetic nervous system/ganglion)
Head/cranial
Ciliary ganglion: roots (Sensory, Parasympathetic, Sympathetic) - Short ciliary
Pterygopalatine ganglion: deep petrosal - nerve of pterygoid canalbranches of distribution: greater palatine (inferior posterior nasal branches) - lesser palatine - nasopalatine (medial superior posterior nasal branches) - pharyngeal
Submandibular ganglionOtic ganglion
Neck/cervical
paravertebral ganglia: Cervical ganglia (Superior, Middle, Inferior) - Stellate ganglionprevertebral plexus: Cavernous plexus - Internal carotid
Chest/thorax
paravertebral ganglia: Thoracic ganglia
prevertebral plexus: Cardiac plexus - Esophageal plexus - Pulmonary plexus - Thoracic aortic plexus
splanchnic nerves: cardiopulmonary - thoraciccardiac nerves: Superior - Middle - Inferior
Abdomen/Lumbar
paravertebral ganglia: Lumbar ganglia
prevertebral ganglia: Celiac ganglia (Aorticorenal) - Superior mesenteric ganglion - Inferior mesenteric ganglion
prevertebral plexus: Celiac plexus - (Hepatic, Splenic, Pancreatic) - aorticorenal (Abdominal aortic plexus, Renal/Suprarenal) - Superior mesenteric (Gastric) - Inferior mesenteric (Spermatic, Ovarian) - Superior hypogastric (hypogastric nerve, Superior rectal) - Inferior hypogastric (Vesical, Prostatic/Cavernous nerves of penis, Uterovaginal, Middle rectal)
splanchnic nerves: Lumbar splanchnic nervesenteric nervous system: Meissner's plexus • Auerbach's plexus
Pelvis/sacral
paravertebral ganglia: Sacral ganglia - Ganglion imparsplanchnic nerves: Pelvic splanchnic nerves - Sacral splanchnic nerves
All
Rami communicans (White, Gray) - Preganglionic fibers - Postganglionic fibers
v • d • eNerves of lower limbs and lower torso: the lumbosacral plexus (L1-Co)
lumbar plexus (L1-L4)
iliohypogastric: lateral cutaneous branch - anterior cutaneous branch
ilioinguinal: anterior scrotal ♂/labial ♀
genitofemoral: femoral branch/lumboinguinal - genital branch
lateral cutaneous of thigh: patellar
obturator: anterior (cutaneous) - posterior - accessoryfemoral: anterior cutaneous branches - saphenous (infrapatellar, medial crural cutaneous)
sacral plexus (L4-S4)
sciatic
common fibular: lateral sural cutaneous (sural communicating branch) - deep fibular (lateral terminal branch, medial terminal branch, dorsal digital) - superficial fibular (medial dorsal cutaneous, intermediate dorsal cutaneous, dorsal digital)
tibial: medial sural cutaneous - medial calcaneal - medial plantar (common plantar digital nerves, proper plantar digital) - lateral plantar (deep branch, superficial branch, common plantar digital, proper plantar digital)sural: lateral dorsal cutaneous - lateral calcaneal
other
muscular: superior gluteal/inferior gluteal - lateral rotator group (to quadratus femoris, to obturator internus, to the piriformis)cutaneous: posterior cutaneous of thigh (inferior cluneal, perineal branches) - perforating cutaneous
coccygeal plexus (S4-Co)
pudendal: inferior anal - perineal (deep, posterior scrotal ♂/labial ♀) - dorsal of the penis ♂/clitoris ♀anococcygeal
cutaneous innervation of the lower limbs
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Categories: Nervous system Neuroanatomy
